Aim: The aim of this study was to improve the categorization of individual cardial risk by a combination of classical cardiovascular risk factors with psychological questionnaires to determine the ability of the individual to cope with stress, and physiological test carried out during mental tasks and during a night period characterized by vagotonia. Method: 130 male volunteers, all Magdeburg University employees, participated in this study, but after consideration of exclusion factors and completeness of the database only 108 of them were finally used for the analysis. Study participants were assigned to one of two groups using cardial risk factors: 42 in the group (HK0) without cardiovascular risk and 66 in the group (HK1) with a detectable cardiovascular risk. Physiological tests (heart rate, heart rate variability, blood pressure) during mental tasks under laboratory conditions, the psychological questionnaires AVEM and SVF, and a 24-h-EKG for analysis of heart rate variability (HRV) were used. Results: The comparison of the two cardiac risk groups revealed a lesser readiness to overdo it professionally but also a smaller tendency to avoid work in the persons in the group HK1. They were less able to cut themselves off socially and reacted less aggressively under stress. The HK1 persons had higher arterial blood pressure than the HK0 persons and a smaller HRV, but the heart rates under laboratory conditions were not different in the two groups. Conclusions: The classical cardiovascular risk factors retain their diagnostic relevance and cannot be replaced by psychological or physiological tests, but these methods can improve the categorization of cardiovascular risk.