Specific protective measures against infections by compiling an adequate spectrum of vaccines and risk-adapted advice for malaria prevention remain a major challenge for anyone counselling travellers. The article gives an update on current recommendations of the German Standing Committee on Vaccinations, on new vaccines on the market and current views concerning indications for vaccination against TBE, Yellow Fever, mumps, measles, rubella, meningococci, points out early signs of HPV vaccine efficacy in the population and sums up trends in malaria transmission and of its reduction.