Aim: The main purpose of this study was to determine vitality and work ability of younger and older managers of a large company. The biological age which characterizes the state of vitality, age-related physical and psychomental indicators, possible health-related and work-related factors and work ability were of particular interest. This study differs from other studies on the health of managers insofar as the focus is on age-related indicators of vitality and potential recourses for influencing age-associated impairment of vitality and work ability during working life, and not on risk factors or risk profiles for illnesses. Sample and Methods: 49 managers (47 male and 2 female which corresponds to a 70% participation rate) participated in this study. Physical and psychomental indicators of vitality were measured by means of a “vitality measuring station”. Work ability was estimated by means of the work ability index. Additional occupational and individual factors influencing vitality and work ability were estimated by means of questionnaires and within an anamnestic interview. Results and Conclusions: The investigated managers were biologically considerably younger than their calendar age (difference: about 8.7 years). The good state of vitality and work ability was particularly evident in older managers. It is assumed that the interaction between several salutogenetic factors (workrelated and individual) contribute to the favourable state of vitality and good work ability in elderly managers. Good ability to cope with a high workload, a high level of work gratification, stable working conditions, pleasure in work and relatively good behaviour with respect to lifestyle and health are particularly noticeable.