More and more people go to high altitude without enough time for proper acclimatization. If there is a lack of time for any reason hypoxic chambers may be used for pre-acclimatisation to avoid altitude diseases. Since there are different protocols and the data differ, there is no general consensus about the standard how to perform pre-acclimatisation by simulated altitude. We review different types of exposure and present target groups which may benefit from pre-acclimatisation. We suggest as the current method of choice the performance of pre-acclimatisation by sleeping some nights at a simulated altitude which follows the altitude profile of the “Gold Standard” for high altitude acclimatisation. Until there are more detailed data about intermittent hypoxia this method should provide the best effect.
